Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

The three-dimensional structure of the first domain of neural cell adhesion molecule

The structure of the N-terminal Ig-superfamily (IgSF) domain of NCAM has a high similarity with the intermediate set of Ig-like domains: the first domain of the vascular cell adhesion molecule (VCAM-1), the M5 domain in titin, and telokin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Barthels, D. et al. EMBO J. 6, 907–914 (1987).

    Article  CAS  Google Scholar 

  2. Cunningham, B.A. et al. Science 236, 799–806 (1987).

    Article  CAS  Google Scholar 

  3. Harrelson, A.L. & Goodman, C.S. Science 242, 700–708 (1988).

    Article  CAS  Google Scholar 

  4. Cremer, H. et al. Nature 367, 455–459 (1994).

    Article  CAS  Google Scholar 

  5. Rønn, L.C.B., Bock, E., Linnemann, D. & Jahnsen, H. Brain Res. 677, 145–151 (1995).

    Article  Google Scholar 

  6. Rao, Y., We, X.-F., Yip, P., Gariepy, J. & Siu, C.-H. J. Biol. Chem. 268, 20630–20638 (1993).

    CAS  PubMed  Google Scholar 

  7. Grumet, M., Flaccus, A. & Margolis, R.U. J. Cell. Biol. 120, 815–824 (1993).

    Article  CAS  Google Scholar 

  8. Nybroe, O., Moran, N. & Bock, E. Neurochem. 52, 1947–1949 (1989).

    Article  CAS  Google Scholar 

  9. Probstmeier, R., Kühn, K. & Schachner, M. J. Neurochem. 53, 1794–1801 (1989).

    Article  CAS  Google Scholar 

  10. Cole, G.J. & Akeson, R. Neuron 2, 1157–1165 (1989).

    Article  CAS  Google Scholar 

  11. Williams, E.J., Furness, J., Walsh, F.S. & Doherty, P. Neuron 13, 583–594 (1994)

    Article  CAS  Google Scholar 

  12. Frei, T., von Bohlen und Halbach, F., Wille W. & Schachner M. J, Cell Biol. 118, 177–194 (1992).

    Article  CAS  Google Scholar 

  13. Jones, E.Y. et al. Nature 373 539–544 (1995).

    Article  CAS  Google Scholar 

  14. Pfuhl, M. & Pastore, A. Structure 3, 391–401 (1995).

    Article  CAS  Google Scholar 

  15. Holden, H.M., Ito, M., Hartshorne, D.J. & Rayment, I. J. Mol. Biol. 227, 840–851 (1992).

    Article  CAS  Google Scholar 

  16. Harpaz, Y. & Chothia, C. J. Mol. Biol. 238, 528–539 (1994).

    Article  CAS  Google Scholar 

  17. Lesk, A.M. & Chothia, C. J. Mol. Biol. 160, 325–342 (1982).

    Article  CAS  Google Scholar 

  18. Haper, E.T. & Rose, G.D. Biochemistry 32, 7605–7610 (1993).

    Article  Google Scholar 

  19. Taylor, R.W. J. Mol. Biol. 188, 233–258 (1986).

    Article  CAS  Google Scholar 

  20. Bashford, D., Chothia, C. & Lesk, A.M. J. Mol. Biol. 196, 199–216 (1987).

    Article  CAS  Google Scholar 

  21. Overduin, M. et al. Science 267, 386–389 (1995).

    Article  CAS  Google Scholar 

  22. Šali, A. & Blundell, T.L. J. Mol. Biol. 234, 779–815 (1993).

    Article  Google Scholar 

  23. Rance et al. Biochem. Biophys. Res. Commun. 2, 479–485 (1983).

    Article  Google Scholar 

  24. Bax, A. & Davis, D.G. J. Magn. Reson. 65, 355–360 (1985).

    CAS  Google Scholar 

  25. Marion, D. et al. Biochemistry 28, 6150–6156 (1989).

    Article  CAS  Google Scholar 

  26. Kay, I.E., Ikura, M., Tschudin, R. & Bax, A. J. Magn. Reson. 89, 496–514 (1990).

    CAS  Google Scholar 

  27. Bax, A. & Ikura, M. J. Biomolec. NMR 1, 99–104 (1991).

    Article  CAS  Google Scholar 

  28. Bax, A., Clore, M. & Gronenborn, A.M. J. Magn. Reson. 88, 425–431 (1990).

    CAS  Google Scholar 

  29. Kjaer, M., Andersen, K.V. & Poulsen, F.M. Meth. Enzym. 239, 288–307 (1994).

    Article  CAS  Google Scholar 

  30. Brünger A.T. X-PLOR Version 3.1. A system for X-ray Crystallography and NMR. Yale University, New Haven CT. (1992).

  31. Kumar, A., Wagner, G., Ernst, R.R. & Wütrich, K. J. Am. Chem. Soc. 103, 3654–3658 (1981).

    Article  CAS  Google Scholar 

  32. Marion, D., Kay, L.E., Sparks, S.W., Torchia, D.A. & Bax, A. J. Amr Chem. Soc. 111, 1515–1517 (1989).

    Article  CAS  Google Scholar 

  33. Nicholls, A. GRASP: Graphical representation and analysis of surface properties (Columbia University, NY, 1993).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thomsen, N., Soroka, V., Jensen, P. et al. The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat Struct Mol Biol 3, 581–585 (1996). https://doi.org/10.1038/nsb0796-581

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0796-581

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing