Structures determined by X-ray crystallography and NMR spectroscopy are averages, whereas many important biological functions require significant departure from the ‘average’ conformation.
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References
Ringe, D., Petsko, G.A., Kerr, D.E. & Ortiz de Montellano, P.R. Biochemistry 23, 2–4 (1984).
Tilton, R.F., Kuntz, I.D. & Petsko, G.A. Biochemistry 12, 2849–2857 (1985).
Poulos, T.L. Pharm. Res. 5, 67–75 (1988).
Lattman, E.E. Proteins Struct Funct. Genet. 25, 1 (1996).
Ringe, D. & Petsko, G.A. Progr. Biophys. Mol. Biol. 45, 197–235 (1985).
Feher, V.A., Baldwin, E.P. & Dahlquist, F.W. Nature Struct. Biol. 3, 516–521 (1996).
Denisov, V.P., Peters, J., Hörlein, H.D. & Halle, B. Nature Struct. Biol. 3, 505–509 (1996).
Fitzgerald, M.M., Musah, R.A., McRee, D.E. & Goodin, D.B. Nature Struct. Biol. 3, 626–631 (1996).
Alber, T. et al. Cold Spring Harbor Symp. Quant. Biol. LII, 603–613 (1988).
Gonzalez, Jr., L., Plecs, J.J. & Alber, T. Nature Struct. Biol. 3, 510–515 (1996).
Phelps, D.K. & Post, C.B. J. Mol. Biol. 254, 544–551 (1995).
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Petsko, G. Not just your average structures. Nat Struct Mol Biol 3, 565–566 (1996). https://doi.org/10.1038/nsb0796-565
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DOI: https://doi.org/10.1038/nsb0796-565