The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-β family, and potential receptor binding surfaces are identified.
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Eigenbrot, C., Gerber, N. X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding. Nat Struct Mol Biol 4, 435–438 (1997). https://doi.org/10.1038/nsb0697-435
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DOI: https://doi.org/10.1038/nsb0697-435
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