The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5′ cap.
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Hodel, A., Gershon, P., Shi, X. et al. Specific protein recognition of an mRNA cap through its alkylated base. Nat Struct Mol Biol 4, 350–354 (1997). https://doi.org/10.1038/nsb0597-350
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DOI: https://doi.org/10.1038/nsb0597-350
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