Examination of FK506, cyclosporin and rapamycin has revealed that the surface loops involved in molecular recognition may need to be rigid as well as hydrophobic.
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Teague, S. Lessons from molecular matchmakers. Nat Struct Mol Biol 2, 360–361 (1995). https://doi.org/10.1038/nsb0595-360
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DOI: https://doi.org/10.1038/nsb0595-360