Defective proteins in the endoplasmic reticulum (ER) are tagged as terminally aberrant by the composition of their N-linked glycans. The ER carbohydrate-binding protein EDEM selectively recognizes such tags and sorts the defective proteins for degradation via the ERAD pathway.
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Wang, T., Hebert, D. EDEM an ER quality control receptor. Nat Struct Mol Biol 10, 319–321 (2003). https://doi.org/10.1038/nsb0503-319
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DOI: https://doi.org/10.1038/nsb0503-319
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