The tide of the blood coagulation cascade turns by a switch in thrombin specificity. Two new structures reveal how thrombomodulin's EGF domains flip the switch by blocking old substrates and docking new ones.
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Acknowledgements
We thank P. Fuentes-Prior and M.J. Wood for providing atomic coordinates, and J. Mamay for helping with figure preparation.
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Overduin, M., de Beer, T. The plot thickens: How thrombin modulates blood clotting. Nat Struct Mol Biol 7, 267–269 (2000). https://doi.org/10.1038/74015
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DOI: https://doi.org/10.1038/74015