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Recognizing misfolded proteins in the endoplasmic reticulum

Nature Structural Biology volume 7, pages 265–266 (2000)Cite this article

The mechanism by which cells recognize misfolded proteins in the endoplasmic reticulum has been defined at the cell biological level. The enzyme UDP-glucose:glycoprotein glucosyltransferase identifies and specifically glucosylates misfolded domains within a multi-domain protein.

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Figure 1: De- and re-glucosylation cycle of the quality control system in the endoplasmic reticulum (ER).

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  1. the Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston , 60208-3500, Illinois, USA

    Andreas Matouschek

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  1. Andreas Matouschek
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Matouschek, A. Recognizing misfolded proteins in the endoplasmic reticulum. Nat Struct Mol Biol 7, 265–266 (2000). https://doi.org/10.1038/74012

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