The human transcription factor, RFX1, is found to belong to the winged-helix family of DNA binding proteins, despite an absence of significant sequence similarity. Even more surprising is the very different mode of DNA binding as compared with previously characterized winged-helix proteins that bind to B-form DNA.
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Wolberger, C., Campbell, R. New perch for the winged helix. Nat Struct Mol Biol 7, 261–262 (2000). https://doi.org/10.1038/74004
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DOI: https://doi.org/10.1038/74004
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