Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track (MGBT).
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References
Harrison, S.C. Nature 353, 715–719 (1991).
Churchill, M.E.A. & Travers, A.A. TIBS 16, 92–97 (1991).
Doherty, A.J., Serpell, L.C. & Ponting, C.P. Nucleic Acids Res. 24, 2488–2497 (1996).
Chandra, A. et al. FEBS Lett. 200, 327–332 (1986).
di Marzo Veronese, F. et al. Science 231, 1289–1291 (1986).
Lightfoote, M.M. et al. J. Virol. 60, 771–775 (1986).
Ollis, D.L., Brick, P., Hamlin, R., Xuong, N.G. & Steitz, T.A. Nature 313, 762–766 (1985).
Kohlstadt, L.A., Wang, J., Freidman, J.M., Rice, P.A. & Steitz, T.A. Science 256, 1783–1790 (1992).
Sousa, R., Chung, Y.J., Rose, J.P. & Wang, B.-C. Nature 364, 593–599 (1993).
Pelletire, H. et al. Science 264, 1891–1903 (1994).
Eom, S.H., Wang, J. & Steitz, T.A. Nature 382, 278–281 (1996).
Jacobo-Molina, A. et al. Proc. Natl. Acad. Sci. U.S.A. 90, 6320–6324 (1993).
Unge, T. et al. Structure 2, 953–961 (1994).
Esnouf, R. et al. Nat. Struct. Biol. 2, 303–308 (1995).
Ren, J. et al. Nat. Struct. Biol. 2, 293–302 (1995).
Beard, W.A. et al. J. Biol. Chem. 269, 28091–28097 (1994)
Bebenek, K. et al. J. Biol. Chem. 270, 19516–19523 (1995).
Beard, W.A. et al. J Biol. Chem. 271, 12213–12210 (1996).
Beese, L.A., Derbyshire, V. & Steitz, T.A. Science 260, 352–355 (1993).
Steitz, T.A. in Biological Organization: Macromolecular Interactions at High Resolution (eds. Burnett, R. & Vogel, H.J.) 45–55 (Academic Press, NY, 1987).
Beard, W.A. et al. J Biol. Chem. 271, 12141–12144 (1996).
Pearlman, D.A. et al. Amber 4.1, University of California, San Francisco (1995).
Darden, T.A., York, D.M. & Pedersen, L. G. J. Chem. Phys. 98, 10089–10092 (1993).
Beard, W.A. & Wilson, S.H. Biochemistry 32, 9745–9753 (1993).
Bebenek, K. & Kunkel, T. A. Meth. Enzymol. 262, 217–231 (1995).
Kroutil, L.C., Register, K., Bebenek, K. & Kunkel, T.A. Biochemistry 35, 1046–1053 (1995).
Kraulis, P. J. Appl. Crystallogr. 24, 946–950 (1991).
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Bebenek, K., Beard, W., Darden, T. et al. A minor groove binding track in reverse transcriptase. Nat Struct Mol Biol 4, 194–197 (1997). https://doi.org/10.1038/nsb0397-194
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DOI: https://doi.org/10.1038/nsb0397-194
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