Neutron diffraction studies show that the inositol ring in the headgroup of phosphatidylinositol extends perpendicular to the membrane surface but that phosphorylation of the 4-position causes the ring to tilt over.
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Bradshaw, J., Bushby, R., Giles, C. et al. Neutron diffraction reveals the orientation of the headgroup of inositol lipids in model membranes. Nat Struct Mol Biol 3, 125–127 (1996). https://doi.org/10.1038/nsb0296-125
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DOI: https://doi.org/10.1038/nsb0296-125
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