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Co-transcriptional monitoring of mRNP formation

Nature Structural Biology volume 10, pages 10–12 (2003)Cite this article

In eukaryotes, newly manufactured mRNA is subject to strict quality control. If certain standards are not met, offending messages are retained in the nucleus and degraded by the exosome complex. New data suggest that exosome-mediated processes are intimately coupled to the transcription machinery, which makes the mRNA in the first place.

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Figure 1: Cartoon showing quality control of nascent eukaryotic mRNA.

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Authors and Affiliations

  1. Department of Molecular and Structural Biology, University of Aarhus, Aarhus C, DK-8000, Denmark

    Torben Heick Jensen

  2. Department of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, 02454, Massachusetts, USA

    Michael Rosbash

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  1. Torben Heick Jensen
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  2. Michael Rosbash
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Jensen, T., Rosbash, M. Co-transcriptional monitoring of mRNP formation. Nat Struct Mol Biol 10, 10–12 (2003). https://doi.org/10.1038/nsb0103-10

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