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May the driving force be with you — whatever it is

Abstract

Changes in the atomic coordinate fluctuations contribute to the entropy of biomolecular processes such as complex formation. Characterizations of such changes in proteins reveal that the response may be dramatically different between the backbone and the side chains, and further resolve enthalpy-entropy compensation at the molecular level.

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Figure 1: Ribbon diagram of GCN4-58 complexed with DNA.

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Correspondence to John Cavanagh or Mikael Akke.

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Cavanagh, J., Akke, M. May the driving force be with you — whatever it is. Nat Struct Mol Biol 7, 11–13 (2000). https://doi.org/10.1038/71202

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