A study investigating the mortality attributed to urolithiasis over a 15-year period has noted an increasing rate of death with a simultaneous rise in stone prevalence. However, the exact mechanisms by which nephrolithiasis causes death remains unclear.
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References
Kum, F. et al. Do stones still kill? An analysis of death from stone disease 1999 to 2013 in England and Wales. BJU Int. http://dx.doi.org/10.1111/bju.13409 (2016).
CDC/NCHS. Mortality by underlying and multiple cause, ages 18+: US, 1981–2013. knoema [online], (2015).
Zisman, A. L., Evan, A. P., Coe, F. L. & Worcester, E. M. Do kidney stone formers have a kidney disease? Kidney Int. 88, 1240–1249 (2015).
El-Zoghby, Z. M. et al. Urolithiasis and the risk of ESRD. Clin. J. Am. Soc. Nephrol. 7, 1409–1415 (2012).
Lindell, A., Denneberg, T. & Granerus, G. Studies on renal function in patients with cystinuria. Nephron 77, 76–85 (1997).
Edvardsson, V. O. et al. Hereditary causes of kidney stones and chronic kidney disease. Pediatr. Nephrol. 28, 1923–1942 (2013).
Saran, R. et al. US renal data system 2014 annual data report: epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 66, A7 (2015).
Sakhaee, K. Epidemiology and clinical pathophysiology of uric acid kidney stones. J. Nephrol. 27, 241–245 (2014).
Unsal, A. et al. Prediction of morbidity and mortality after percutaneous nephrolithotomy by using the Charlson Comorbidity Index. Urology 79, 55–60 (2012).
Kreydin, E. I. & Eisner, B. H. Risk factors for sepsis after percutaneous renal stone surgery. Nat. Rev. Urol. 10, 598–605 (2013).
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Rivera, M., Krambeck, A. The dark side of stone disease — stones do still kill. Nat Rev Urol 13, 247–248 (2016). https://doi.org/10.1038/nrurol.2016.56
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DOI: https://doi.org/10.1038/nrurol.2016.56