2013 witnessed advances in many aspects of multiple sclerosis (MS) research. Two studies highlighted a potential role for salt as an MS trigger, and one immunomodulatory drug performed well in clinical trials. Moreover, treatment effects of MS drugs were shown to correlate inversely with brain atrophy and disease progression.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wu, C. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513–517 (2013).
Kleinewietfeld, M. et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 496, 518–522 (2013).
Nicoletti, A. et al. Voluptuary habits and clinical subtypes of Parkinson's disease: the FRAGAMP case control study. Mov. Disord. 25, 2387–2394 (2010).
Manouchehrinia, A. et al. Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study. Brain 136, 2298–2304 (2013).
Wynn, D. et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol. 9, 381–390 (2010).
Gold, R. et al. Daclizumab high-yield process in relapsing–remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial. Lancet 381, 2167–2175 (2013).
International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214–219 (2011).
Sormani, M. P., Arnold, D. L. & De Stefano, N. Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis. Ann. Neurol. http://dx.doi.org/10.1002/ana.24018.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
X. Montalban has received honoraria and reimbursement for travel expenses for participation in scientific meetings, and has received fees for work performed in relation to steering committees of clinical trials. These are the companies that have paid honoraria and/or fees: Biogen Idec, Merck, Novartis, Teva, Bayer, Almirall, Genzyme, Sanofi, Roche, GeNeuro. Mar Tintoré has received honoraria and reimbursement for travel expenses for participation in scientific meetings. These are the companies that have paid honoraria and/or fees: Biogen Idec, Merck, Novartis, Teva, Bayer, Genzyme.
Rights and permissions
About this article
Cite this article
Montalban, X., Tintoré, M. Novel triggers, treatment targets and brain atrophy measures. Nat Rev Neurol 10, 72–73 (2014). https://doi.org/10.1038/nrneurol.2013.274
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2013.274
This article is cited by
-
Immuntherapie der multiplen Sklerose
Der Internist (2015)