New-generation oral anticoagulants carry a lower risk of intracranial haemorrhage (ICH) than does warfarin, a new systematic review and meta-analysis shows. Chatterjee et al. analysed six studies, which had recruited a total of 57,491 patients with atrial fibrillation who received anticoagulants for stroke prevention. All novel anticoagulants, which interact directly with coagulating proteins, were associated with a 50% reduced risk of ICH compared with warfarin-based vitamin K antagonists.