Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Multiple sclerosis

Autoimmune associations in multiple sclerosis

The growing literature on comorbidity in multiple sclerosis (MS)—in particular, the association of MS with other autoimmune diseases—provides interesting clues to the complex pathogenesis of this disease, but also raises awareness of the important issues that need to be considered in its management.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Langer-Gould, A., Albers, K. B., Van Den Eeden, S. K. & Nelson, L M. Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case–control study. Mult. Scler. 16, 855–861 (2010).

    Article  CAS  Google Scholar 

  2. Ramagopalan, S. V., Knight, J. C. & Ebers, G. C. Multiple sclerosis and the major histocompatibility complex. Curr. Opin. Neurol. 22, 219–225 (2009).

    Article  CAS  Google Scholar 

  3. Zuvich, R. L., McCauley, J. L., Pericak-Vance, M. A. & Haines, J. L. Genetics and pathogenesis of multiple sclerosis. Semin. Immunol. 21, 328–333 (2009).

    Article  CAS  Google Scholar 

  4. Barcellos, L. F. et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol. 5, 924–931 (2006).

    Article  CAS  Google Scholar 

  5. Ramagopalan, S. V. et al. Autoimmune disease in families with multiple sclerosis: a population-based study. Lancet Neurol. 6, 604–610 (2007).

    Article  Google Scholar 

  6. Edwards, L. J. & Constantinescu, C. S. A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult. Scler. 10, 575–581 (2004).

    Article  CAS  Google Scholar 

  7. Hooper, D. C. et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl Acad. Sci. USA 95, 675–680 (1998).

    Article  CAS  Google Scholar 

  8. Marrie, R. A. et al. Comorbidity delays diagnosis and increases disability at diagnosis in MS. Neurology 72, 117–124 (2009).

    Article  CAS  Google Scholar 

  9. Frischer, J. M. et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 132, 1175–1189 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cris S. Constantinescu.

Ethics declarations

Competing interests

C. S. Constantinescu has received research support and travel support to scientific meetings from Bayer-Schering, Biogen Idec, Merck-Serono and TEVA, and consultancy fees from Novartis, and has been on the advisory board of Bayer-Schering, Biogen Idec and TEVA. B. Gran has received research support and travel support to scientific meetings from Bayer-Schering, Biogen Idec, Merck-Serono and TEVA.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Constantinescu, C., Gran, B. Autoimmune associations in multiple sclerosis. Nat Rev Neurol 6, 591–592 (2010). https://doi.org/10.1038/nrneurol.2010.147

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2010.147

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing