The growing literature on comorbidity in multiple sclerosis (MS)—in particular, the association of MS with other autoimmune diseases—provides interesting clues to the complex pathogenesis of this disease, but also raises awareness of the important issues that need to be considered in its management.
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References
Langer-Gould, A., Albers, K. B., Van Den Eeden, S. K. & Nelson, L M. Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case–control study. Mult. Scler. 16, 855–861 (2010).
Ramagopalan, S. V., Knight, J. C. & Ebers, G. C. Multiple sclerosis and the major histocompatibility complex. Curr. Opin. Neurol. 22, 219–225 (2009).
Zuvich, R. L., McCauley, J. L., Pericak-Vance, M. A. & Haines, J. L. Genetics and pathogenesis of multiple sclerosis. Semin. Immunol. 21, 328–333 (2009).
Barcellos, L. F. et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol. 5, 924–931 (2006).
Ramagopalan, S. V. et al. Autoimmune disease in families with multiple sclerosis: a population-based study. Lancet Neurol. 6, 604–610 (2007).
Edwards, L. J. & Constantinescu, C. S. A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult. Scler. 10, 575–581 (2004).
Hooper, D. C. et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl Acad. Sci. USA 95, 675–680 (1998).
Marrie, R. A. et al. Comorbidity delays diagnosis and increases disability at diagnosis in MS. Neurology 72, 117–124 (2009).
Frischer, J. M. et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 132, 1175–1189 (2009).
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C. S. Constantinescu has received research support and travel support to scientific meetings from Bayer-Schering, Biogen Idec, Merck-Serono and TEVA, and consultancy fees from Novartis, and has been on the advisory board of Bayer-Schering, Biogen Idec and TEVA. B. Gran has received research support and travel support to scientific meetings from Bayer-Schering, Biogen Idec, Merck-Serono and TEVA.
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Constantinescu, C., Gran, B. Autoimmune associations in multiple sclerosis. Nat Rev Neurol 6, 591–592 (2010). https://doi.org/10.1038/nrneurol.2010.147
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DOI: https://doi.org/10.1038/nrneurol.2010.147
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