A study has demonstrated that acute glomerular inflammation increases the time that leukocytes are retained in capillaries, rather than increasing leukocyte recruitment, as was previously thought. Devi et al. used multiphoton confocal microscopy to show that leukocytes were present in capillaries of normal glomeruli, where they remained static or migrated intravascularly. Induction of inflammation resulted in an increase in the duration of leukocyte retention. The researchers say their findings describe a new paradigm in glomerular inflammation.
ORIGINAL RESEARCH PAPER
Devi, S. et al. Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat. Med. doi:10.1038/nm.3024
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A new paradigm for glomerular leukocyte recruitment. Nat Rev Nephrol 9, 65 (2013). https://doi.org/10.1038/nrneph.2012.273
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DOI: https://doi.org/10.1038/nrneph.2012.273