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Polycystic kidney disease

The cadence of kidney growth in ADPKD

Autosomal-dominant polycystic kidney disease is characterized by the development and expansion of cysts, which ultimately results in kidney failure. The rate of this expansion can now be quantified within a short period of time, which has implications for assessing the risk of renal failure in affected patients.

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References

  1. Torres, V. E., Harris, P. C. & Pirson, Y. Autosomal dominant polycystic kidney disease. Lancet 369, 1287–1301 (2007).

    Article  Google Scholar 

  2. Perrone, R. D., Ruthazer, R. & Terrin, N. C. Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality. Am. J. Kidney Dis. 38, 777–784 (2001).

    Article  CAS  Google Scholar 

  3. Cadnapaphornchai, M. A., McFann, K., Strain, J. D., Masoumi, A. & Schrier, R. W. Prospective change in renal volume and function in children with ADPKD. Clin. J. Am. Soc. Nephrol. 4, 820–829 (2009).

    Article  CAS  Google Scholar 

  4. Fick-Brosnahan, G. M., Tran, Z. V., Johnson, A. M., Strain, J. D. & Gabow, P. A. Progression of autosomal-dominant polycystic kidney disease in children. Kidney Int. 59, 1654–1662 (2001).

    Article  CAS  Google Scholar 

  5. Kistler, A. D. et al. Increases in kidney volume in autosomal dominant polycystic kidney disease can be detected within 6 months. Kidney Int. 75, 235–241 (2009).

    Article  Google Scholar 

  6. Grantham, J. J. et al. Volume progression in polycystic kidney disease. N. Engl. J. Med. 354, 2122–2130 (2006).

    Article  CAS  Google Scholar 

  7. Chapman, A. B. et al. Total kidney volume (TKV) and clinical complications in ADPKD [abstract]. J. Am. Soc. Nephrol. 19, 124A (2008).

    Google Scholar 

  8. Rossetti, S. et al. Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease. J. Am. Soc. Nephrol. 18, 2143–2160 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by a PHS Grant UL1 RR025008 from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources.

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Chapman, A. The cadence of kidney growth in ADPKD. Nat Rev Nephrol 5, 311–312 (2009). https://doi.org/10.1038/nrneph.2009.75

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