Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transplantation

Kidney or kidney–pancreas transplant for the uremic diabetic?

Nature Reviews Nephrology volume 5, pages 554–555 (2009)Cite this article

Uremic diabetics have better survival rates with a kidney transplant than on dialysis. Adding a pancreas graft induces insulin independence and if the graft survives for >1 year, risk-adjusted registry analyses show improved patient and graft survival. Overall, however, as survival is similar for kidney–pancreas and kidney transplants alone from deceased pancreas donors, many questions remain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Patient survival after a deceased donor pancreas transplant (US cases in the period 2004–2008) in diabetic recipients of a previous kidney transplant from living or deceased donors.

References

  1. Gruessner, A. C. & Sutherland, D. E. R. Pancreas Transplant Outcomes for United States (US) Cases as Reported to the United Network For Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). Clinical Transplants 2008 Ch. 4 (eds Cecka, J. M. & Terasaki, P. I.) 45–56 (Terasaki Foundation Laboratory, Los Angeles, 2009).

    Google Scholar 

  2. Weiss, A. S., Smits, G. & Wiseman, A. C. Simultaneous pancreas-kidney versus deceased donor kidney transplant: can a fair comparison be made? Transplantation 87, 1402–1410 (2009).

    Article  PubMed  Google Scholar 

  3. Weiss, A. S., Smits, G. & Wiseman, A. C. Twelve-month pancreas graft function significantly influences survival following simultaneous pancreas-kidney transplantation. Clin. J. Am. Soc. Nephrol. 4, 988–995 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Kleinclauss, F. et al. Pancreas after living donor kidney transplants in diabetic patients: impact on long-term kidney graft function. Clin. Transplant. 23, 437–446 (2009).

    Article  PubMed  Google Scholar 

  5. Fridell, J. A. et al. The case for pancreas after kidney transplantation. Clin. Transplant. 23, 447–453 (2009).

    Article  PubMed  Google Scholar 

  6. Venstrom, J. M. et al. Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA 290, 2817–2823 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Gruessner, R. W., Sutherland, D. E. & Gruessner, A. C. Mortality assessment for pancreas transplants. Am. J. Transplant. 4, 2018–2026 (2004).

    Article  PubMed  Google Scholar 

  8. Kaufman, D. B. Pancreas-after-kidney transplantation: to have and not have not. Clin. Transplant. 23, 435–436 (2009).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Minnesota, Minneapolis, MN, USA

    David E. R. Sutherland

  2. Epidemiology/Biostatistics Division, School of Medicine, University of Arizona, Tucson, AZ, USA

    Angelika C. Gruessner

  3. Departments of Surgery and Health Services Research and Policy, University of Minnesota, Minneapolis, MN, USA

    David M. Radosevich

Authors
  1. David E. R. Sutherland
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angelika C. Gruessner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David M. Radosevich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David E. R. Sutherland.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sutherland, D., Gruessner, A. & Radosevich, D. Kidney or kidney–pancreas transplant for the uremic diabetic?. Nat Rev Nephrol 5, 554–555 (2009). https://doi.org/10.1038/nrneph.2009.149

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2009.149

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing