Graft stenosis, which can lead to thrombosis, is a major problem in hemodialysis patients with arteriovenous grafts. Does anti-aggregation with dipyridamole and aspirin help to prolong the primary patency of vascular access grafts?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dixon, B. S. et al. Effect of dipyridamole plus aspirin on hemodialysis graft patency. N. Engl. J. Med. 360, 2191–2201 (2009).
Tordoir, J. et al. EBPG on Vascular Access. Nephrol. Dial. Transplant. 22 (Suppl. 2), ii88–ii117 (2007).
Yahav, D. et al. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. Clin. Infect. Dis. 47, 83–93 (2008).
Dember, L. M. et al. Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA 299, 2164–2171 (2008).
Kaufman, J. S. et al. Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis. J. Am. Soc. Nephrol. 14, 2313–2321 (2003).
Osborn, G., Escofet, X. & Da, S. A. Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts. Cochrane Database of Systematic Reviews, Issue 2. Art. No. CD002786. doi:10.1002/14651858.CD002786.pub2 (2008).
ESPRIT Study Group et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367, 1665–1673 (2006).
Chesebro, J. H. et al. Effect of dipyridamole and aspirin on late vein-graft patency after coronary bypass operations. N. Engl. J. Med. 310, 209–214 (1984).
Hess, H., Mietaschk, A. & Deichsel, G. Drug-induced inhibition of platelet function delays progression of peripheral occlusive arterial disease. A prospective double-blind arteriographically controlled trial. Lancet 1, 415–419 (1985).
Diener, H. C. et al. European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J. Neurol. Sci. 143, 1–13 (1996).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Vanholder, R., Verbeke, F. & Van Biesen, W. Vascular access: not enough light at the end of the tunnel?. Nat Rev Nephrol 5, 551–552 (2009). https://doi.org/10.1038/nrneph.2009.144
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2009.144