Adult neurogenesis is supported by the vasculature, but the contribution of different vascular cell types to this support is not clear. Here, the authors found that both pericytes and endothelial cells from the mouse ventricular–subventricular zone (V–SVZ), a key neurogenic niche, promoted proliferation and differentiation of neural stem cells in vitro. Unexpectedly, they also showed that isolated vascular cells from the cortex, a non-neurogenic region, supported these processes even more potently. Thus, vascular cells in non-neurogenic regions may have a latent capacity to support neurogenesis.
References
Crouch, E. E. et al. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J. Neurosci. 35, 4528–4539 (2015)
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Carr, F. Support from the cortex. Nat Rev Neurosci 16, 248 (2015). https://doi.org/10.1038/nrn3958
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DOI: https://doi.org/10.1038/nrn3958
