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Neuronal migration

Signalling retreat

Nature Reviews Neuroscience volume 8, pages 410–411 (2007)Cite this article

Migrating neurons navigate their environment by responding to various extracellular guidance cues. Coordination of the behaviour of the growth cone and the translocation of the cell body is essential, yet the means by which this is achieved are unknown. Poo and colleagues now reveal a mechanism by which growth cones can relay such guidance signals to the cell body.

These findings implied that a long-range signal from the growth cone must trigger the reversal of cell soma translocation. The authors revealed that intracellular Ca2+ levels increased within seconds of SLIT2 exposure. Moreover, stimulating Ca2+ release from intracellular stores with low-level ryanodine treatment triggered the reversal of soma translocation, whereas blocking Ca2+ release from these stores with high levels of ryanodine abolished the SLIT2-triggered reversal of translocation. This indicated that a propagated Ca2+wave triggers SLIT2-induced reversal of translocation.

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ORIGINAL RESEARCH PAPER

  1. Guan, C.-B. et al. Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2. Cell 129, 385–395 (2007)

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  1. Katherine Whalley
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Whalley, K. Signalling retreat. Nat Rev Neurosci 8, 410–411 (2007). https://doi.org/10.1038/nrn2157

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