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Sensing by bacterial regulatory systems in host and non-host environments

Nature Reviews Microbiology volume 4, pages 705–709 (2006)Cite this article

Abstract

Free-living organisms have the ability to gauge their surroundings and modify their gene expression patterns in ways that help them cope with new environments. Here we discuss the physiological significance of recent reports describing the ability of the Salmonella typhimurium PhoP/PhoQ two-component system to recognize and respond to host-derived antimicrobial peptides.

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Figure 1: Model illustrating the PhoP/PhoQ regulatory network of Salmonella enterica serovar Typhimurium (S. typhimurium).

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Acknowledgements

We thank members of our laboratory for discussions. Our research on the PhoP/PhoQ system is funded in part by the National Institutes of Health. E.A.G. is an investigator of the Howard Hughes Medical Institute.

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  1. Department of Molecular Microbiology, Washington University School of Medicine, Campus P.O. Box 8230, 660 South Euclid Avenue, St. Louis, 63110, Missouri, USA

    Eduardo A. Groisman & Chakib Mouslim

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Correspondence to Eduardo A. Groisman.

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DATABASES

Entrez Genome Project

Agrobacterium tumefaciens

Azotobacter vinelnadii

Brucella suis

Erwinia chrysanthemi

Escherichia coli

Klebsiella pneumoniae

Photorhabdus luminescens

Photobacterium profundum SS9

Pseudomonas aeruginosa

Salmonella typhimurium

Shigella flexneri

Vibrio cholerae

Yersinia pestis

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Groisman, E., Mouslim, C. Sensing by bacterial regulatory systems in host and non-host environments. Nat Rev Microbiol 4, 705–709 (2006). https://doi.org/10.1038/nrmicro1478

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