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Regulatory T cells

Back in fashion

Nature Reviews Immunology volume 2, pages 148–149 (2002)Cite this article

B. pertussis is a pathogen of the respiratory tract. Recovery from infection is dependent on the development of B. pertussis-specific TH1 cells, although the TH1 response is suppressed during the acute phase of infection. Previous work by Mills et al. has shown that the B. pertussis virulence factor filamentous haemagglutinin (FHA) can inhibit lipopolysaccharide (LPS)-stimulated interleukin-12 (IL-12) production by macrophages. In the present study, the role of FHA in suppression of TH1 responses by induction of regulatory T cells was examined.

The authors first looked at the effect of FHA on cytokine production by immature bone-marrow-derived dendritic cells (DCs). FHA stimulated IL-10 production by DCs and suppressed LPS- and interferon-γ (IFN-γ)-induced production of IL-12. Because IL-10 seems to be required for the induction of T regulatory 1 (Tr1) cells, the authors next looked for evidence of Tr1 induction during the acute phase of responses to B. pertussis, when TH1 responses are suppressed. Tr1-like lines and clones were derived from the lungs of mice acutely infected with B. pertussis by culturing lung T cells with antigen-presenting cells (APCs) and FHA (which stimulates IL-10 production by the APCs). The Tr1 clones secreted high levels of IL-10 and IL-5 and moderate levels of transforming growth factor-β, but little or no IFN-γ, IL-2 or IL-4.

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References

ORIGINAL RESEARCH PAPER

  1. McGuirk, P., McCann, C. & Mills, K. H. G. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 1 production by dendritic cells: a novel strategy for evasion of protective helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195, 221–231 (2002). http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11805149&dopt=Abstract

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FURTHER READING

  1. Read, S. & Powrie, F. CD4(+) regulatory T cells. Curr. Opin. Immunol. 13, 644–649. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11677084&dopt=Abstract

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  1. Elaine Bell
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Bell, E. Back in fashion. Nat Rev Immunol 2, 148–149 (2002). https://doi.org/10.1038/nri752

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  • DOI: https://doi.org/10.1038/nri752

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