Findings from a new, multinational, randomized, controlled trial suggest that histamine receptor 2 antagonists and PPIs are equal in their ability to control peptic ulcer rebleeding. However, several methodological issues of this study limit the conclusions that can be drawn from it.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Barkun, A. N., Martel, M., Toubouti, Y., Rahme, E. & Bardou, M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointest. Endosc. 69, 786–799 (2009).
Leontiadis, G. I., Sharma, V. K. & Howden, C. W. Proton pump inhibitor treatment for acute peptic ulcer bleeding. Cochrane Database of Systematic Reviews Issue 1. Art. No.: CD002094. doi:10.1002/14651858.CD002094.pub3 (2006).
van Rensburg, C. et al. Clinical trial: intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: a multicentre, multinational, randomized trial. Aliment. Pharmacol. Ther. 29, 497–507 (2009).
Barkun, A. et al. Prevention of peptic ulcer rebleeding using continuous infusion of pantoprazole vs ranitidine: a mulitcenter, multinational, randomized, double-blind, parallel-group comparison [Abstract]. Gastroenterology 126 (Suppl. 2), A78 (2004).
Chiu, P. W. et al. Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy. Clin. Gastroenterol. Hepatol. 7, 311–316 (2009).
Lau, J. Y. et al. Stigmata of hemorrhage in bleeding peptic ulcers: an interobserver agreement study among international experts. Gastrointest. Endosc. 46, 33–36 (1997).
Lin, H. J., Lo, W. C., Lee, F. Y., Perng, C. L. & Tseng, G. Y. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch. Intern. Med. 158, 54–58 (1998).
Andriulli, A. et al. High- versus low-dose proton pump inhibitors after endoscopic hemostasis in patients with peptic ulcer bleeding: a multicenter, randomized study. Am. J. Gastroenterol. 103, 3011–3018 (2008).
Tsai, J. J., Hsu, Y. C., Perng, C. L. & Lin, H. J. Oral or intravenous proton pump inhibitor in patients with peptic ulcer bleeding after successful endoscopic epinephrine injection. Br. J. Clin. Pharmacol. 67, 326–332 (2009).
Lau, J. Y. et al. Omeprazole before endoscopy in patients with gastrointestinal bleeding. N. Engl. J. Med. 356, 1631–1640 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Hsu, YC., Lin, HJ. Adjuvant pharmacotherapy for peptic ulcer bleeding. Nat Rev Gastroenterol Hepatol 6, 450–452 (2009). https://doi.org/10.1038/nrgastro.2009.121
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2009.121