Kim et al. used in vitro and mouse studies to identify a gut–heart axis involved in the regulation of blood pressure. In this axis, activation of the glucagon-like peptide-1 receptor (GLP-1R) leads to secretion of atrial natriuretic peptide (ANP) and reduction in blood pressure. Furthermore, the Rap guanine nucleotide exchange factor Epac2 (also known as Rapgef4) was identified as a downstream target of GLP-1R in cardiomyocytes. The investigators call for more research on the metabolic and cardiovascular effects of ANP as a downstream target of GLP-1 action.
ORIGINAL RESEARCH PAPER
Kim, M. et al. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat. Med. doi:10.1038/nm.3128
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A novel GLP-1–ANP axis controls blood pressure. Nat Rev Endocrinol 9, 380 (2013). https://doi.org/10.1038/nrendo.2013.91
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DOI: https://doi.org/10.1038/nrendo.2013.91