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Does TSH concentration influence skeletal health?

Nature Reviews Endocrinology volume 5, pages 245–246 (2009)Cite this article

Controversy surrounds the skeletal consequences of altered thyroid function. According to the latest report from the Tromsø population survey, however, variations of serum TSH concentration that remain within the normal range do not greatly influence BMD.

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References

  1. Murphy, E. & Williams, G. R. The thyroid and the skeleton. Clin. Endocrinol. (Oxf.) 61, 285–298 (2004).

    Article  CAS  Google Scholar 

  2. Vestergaard, P. & Mosekilde, L. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid 12, 411–419 (2002).

    Article  Google Scholar 

  3. Uzzan, B. et al. Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J. Clin. Endocrinol. Metab. 81, 4278–4289 (1996).

    CAS  PubMed  Google Scholar 

  4. Grimnes, G., Emaus, N., Joakimsen, R. M., Figenschau, Y. & Jorde, R. The relationship between serum TSH and bone mineral density in men and postmenopausal women: the Tromsø study. Thyroid 18, 1147–1155 (2008).

    Article  CAS  Google Scholar 

  5. Bauer, D. C., Ettinger, B., Nevitt, M. C. & Stone, K. L. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann. Intern. Med. 134, 561–568 (2001).

    Article  CAS  Google Scholar 

  6. Bassett, J. H. & Williams, G. R. Critical role of the hypothalamic–pituitary–thyroid axis in bone. Bone 43, 418–426 (2008).

    Article  CAS  Google Scholar 

  7. Majima, T. et al. Clinical significance of risedronate for osteoporosis in the initial treatment of male patients with Graves' disease. J. Bone Miner. Metab. 24, 105–113 (2006).

    Article  CAS  Google Scholar 

Download references

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  1. Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA

    Douglas C. Bauer

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  1. Douglas C. Bauer
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Correspondence to Douglas C. Bauer.

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The author declares no competing financial interests.

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Bauer, D. Does TSH concentration influence skeletal health?. Nat Rev Endocrinol 5, 245–246 (2009). https://doi.org/10.1038/nrendo.2009.59

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  • DOI: https://doi.org/10.1038/nrendo.2009.59

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