Despite the increasing implementation of iodization programs, benign nodular thyroid disease will remain a prevalent therapeutic concern for decades. Recent research suggests that nonsurgical therapy, including radioactive iodine, radiofrequency thermal ablation and percutaneous laser ablation, might have a role in the treatment of symptomatic patients.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up
BMC Cancer Open Access 13 February 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hegedüs, L., Bonnema, S. J. & Bennedbaek, F. N. Management of simple and nodular goiter: current status and future perspectives. Endocr. Rev. 24, 102–132 (2003).
Hegedüs, L. Clinical practice. The thyroid nodule. N. Engl. J. Med. 351, 1764–1771 (2004).
Watt, T. et al. Quality of life in patients with benign thyroid disorders. A review. Eur. J. Endocrinol. 154, 501–510 (2006).
Spiezia, S. et al. Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid 19, 219–225 (2009).
Gharib, H. et al. American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr. Pract. 12, 63–102 (2006).
Fast, S., Nielsen, V. E., Bonnema, S. J. & Hegedüs, L. Time to reconsider nonsurgical therapy of benign non-toxic multinodular goitre: focus on recombinant human TSH augmented radioiodine therapy. Eur. J. Endocrinol. 160, 517–528 (2009).
Gharib, H. & Papini, E. Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol. Metab. Clin. North Am. 36, 707–735 (2007).
Bennedbaek, F. N. & Hegedüs, L. Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial. J. Clin. Endocrinol. Metab. 88, 5773–5777 (2003).
Døssing, H., Bennedbaek, F. N. & Hegedüs, L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments. Thyroid 16, 763–768 (2006).
Esnault, O., Franc, B., Monteil, J. P. & Chapelon, J. Y. High-intensity focused ultrasound for localized thyroid-tissue ablation: preliminary experimental animal study. Thyroid 14, 1072–1076 (2004).
Acknowledgements
I wish to express my gratitude to Steen J. Bonnema, Finn N. Bennedbaek, Viveque Egsgaard, Helle Døssing, and Søren Fast for valuable discussion and collaboration on this theme. The Novo Nordisk Foundation is thanked for economic support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares associations with the following companies: Genzyme (consultant, speaker's bureau, grant/research support), Theraclion (consultant).
Rights and permissions
About this article
Cite this article
Hegedüs, L. A new nonsurgical therapy option for benign thyroid nodules?. Nat Rev Endocrinol 5, 476–478 (2009). https://doi.org/10.1038/nrendo.2009.152
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2009.152
This article is cited by
-
Balanced Arguments Against RFA in the Neck: a Surgeon’s Perspective
Current Otorhinolaryngology Reports (2021)
-
Technique and Procedural Aspects of Radiofrequency Ablation of Thyroid Nodules
Current Otorhinolaryngology Reports (2021)
-
Radiofrequency ablation and thyroid nodules: updated systematic review
Endocrine (2021)
-
Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up
BMC Cancer (2019)
-
High-intensity focused ultrasound (HIFU) for benign thyroid nodules: 2-year follow-up results
Endocrine (2019)
