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Protein Folding and Disease: a view from the first Horizon Symposium

Nature Reviews Drug Discovery volume 2, pages 154–160 (2003)Cite this article

Abstract

October 2002 saw the launch of a new series of discussion meetings, the Horizon Symposia, organized jointly by Nature Publishing Group and Aventis. Chris Dobson was invited to act as rapporteur for the inaugural Symposium, on the topic of 'Protein Folding and Disease'. In this article he brings together some of the threads of the meeting to give a personal 'snapshot' of the state of play in this fast-moving interdisciplinary field.

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Figure 1: Energy landscape for protein folding.
Figure 2: States accessible to a protein molecule.
Figure 3: The endoplasmic reticulum and protein folding.
Figure 4: General mechanism of aggregation of disease-associated proteins.

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  1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    Christopher M. Dobson

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  1. Christopher M. Dobson
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DATABASES

LocusLink

α1-antitrypsin

α-lactalbumin

α-synuclein

transthyretin

FURTHER INFORMATION

The Horizon Symposia

The Horizon Symposia

Key Questions

Technological challenges of studying protein folding

Cell biology of protein folding

Basic mechanisms of protein folding diseases

Therapeutic strategies for protein folding disease

Encyclopedia of Life Sciences

Chaperonins

Chaperones, chaperonin and heat-shock proteins

Protein folding in vivo

Protein folding: overview of pathways

Recent Nature Reviews Drug Discovery highlights on protein folding

Assembly instructions

A therapeutic knockout of SAP

The early results of misfolding

Toxic waste

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Dobson, C. Protein Folding and Disease: a view from the first Horizon Symposium. Nat Rev Drug Discov 2, 154–160 (2003). https://doi.org/10.1038/nrd1013

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