A comparison of datasets from The Cancer Genome Atlas and the Cancer Cell Line Encyclopedia has shown that ovarian cancer cell lines used in research might not be good models of ovarian cancer. About 50 ovarian cancer cell lines were ranked according to their genomic similarity to clinical samples of high-grade serous ovarian cancer (HGSOC). The two most-popular cell lines, used in 60% of publications on HGSOC, did not resemble HGSOC well; the 12 cell lines that most closely resembled HGSOC were used in only 1% of publications. Similar studies could be used for other cancer cell lines to assess their relevance to the clinical situation.
ORIGINAL RESEARCH PAPER
Domcke, S. et al. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 10.1038/ncomms3126
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Evaluating ovarian cancer cell lines as tumour models. Nat Rev Clin Oncol 10, 486 (2013). https://doi.org/10.1038/nrclinonc.2013.126
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DOI: https://doi.org/10.1038/nrclinonc.2013.126
