Tumour-associated macrophages have been linked with a poor outcome in patients with Hodgkin lymphoma. In a multicentre phase III trial of 287 patients randomized to a training cohort and validation cohort, increased expression levels of CD68 and CD163 were significantly associated with worse failure-free and overall survival outcomes in the validation cohort. Analysis of the validation cohort showed both markers were independent predictors of inferior survival outcomes, and thus have prognostic significance.
ORIGINAL RESEARCH PAPER
Tan, K. L. et al. Tumor-associated macrophages predict inferior outcomes in classical Hodgkin lymphoma: a correlative study from the E2496 Intergroup study. Blood doi:10.1182/blood-2012-04-421057
Rights and permissions
About this article
Cite this article
TAM predict inferior outcome in Hodgkin lymphoma. Nat Rev Clin Oncol 9, 611 (2012). https://doi.org/10.1038/nrclinonc.2012.179
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrclinonc.2012.179