Abstract
The occurrence of seizures is a rare event with a very low probability of incidence. Therefore, a new paradigm is required to understand how epileptic seizures are generated. Specifically, analytical models and experimental data analysis show that the process underlying seizure generation is a severe dysfunctional regulation of neuronal activity inside the epileptogenic region. Translated into significant changes of endogenous electric field, this dysfunction acts at fundamental level of charge dynamics and leads to chaotic diffusion and electrical resonances within clustered regions with high frequency oscillations (HFO). Since the altered regulation can be modeled by perturbed Hamiltonian systems with many degrees of freedom that describe the motion of charged particles in electric field, the Kolmogorov Arnold Moser theory (KAM) provides a physical model for the mechanism of epileptogenesis. Contrary to common belief, either inhibitory or excitatory function models of chronic epilepsy are incomplete and inconsistent.
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Aur, D. The Physical Mechanism in Epilepsy - Understanding the Transition to Seizure. Nat Prec (2010). https://doi.org/10.1038/npre.2010.5398.1
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DOI: https://doi.org/10.1038/npre.2010.5398.1
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