Abstract
Mice that express the mutant form of the human amyloid precursor gene associated with early-onset familial Alzheimer's disease demonstrate memory deficits and amyloid plaques. We show here that ciproxifan, a prototypical antagonist of H~3~-type histamine receptors, alleviates two types of learning and memory impairments in such mice. These data support the idea that modulation of H~3~ receptors represents a viable therapeutic strategy in the treatment of Alzheimer's disease.
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Bardgett, M., Davis, N. & Griffith, M. Ciproxifan, an H~3~ Receptor Antagonist, Improves Learning and Memory in the APP Mouse Model of Alzheimer's Disease. Nat Prec (2009). https://doi.org/10.1038/npre.2009.4041.1
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DOI: https://doi.org/10.1038/npre.2009.4041.1