Abstract
The density of α2-adrenoceptors, using 3H-idazoxan as the radioligand, was determined by quantitative autoradiography in the locus coeruleus and in 13 noradrenergic projection fields following chronic administration of drugs acting on noradrenergic and/or serotonergic neurons. Protriptyline, an inhibitor of the uptake of norepinephrine, and mianserin, an α2-adrenoceptor antagonist, reduced the binding of 3H-idazoxan only in the locus coeruleus. Phenelzine, an inhibitor of both type A and type B monoamine oxidase (MAO), reduced the binding of 3H-idazoxan in the locus coeruleus and in several areas with noradrenergic innervation from tegmental cell bodies. Clorgyline, a selective inhibitor of type A MAO, had no effect. Of the two selective inhibitors of serotonin uptake, citalopram caused a modest increase in binding only in one terminal field area, whereas sertraline had no effect. Although these antidepressants did not produce consistent effects on α2-adrenoceptors, protriptyline, mianserin, and phenelzine were similar in that they all decreased the binding of 3H-idazoxan in the locus coeruleus without widely affecting its binding in the coerulean terminal fields. Deprenyl, a selective inhibitor of type B MAO, the only drug in this study without proven antidepressant efficacy, differed from all other drugs in that it decreased the binding of 3H-idazoxan both in the locus coeruleus as well as in most terminal fields with primarily coerulean noradrenergic innervation.
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Address reprint requests to: Gyula B. Kovachich, Ph.D., Neuropsychopharmacology Unit (151E), Department of Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, Pennsylvania 19104.
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Kovachich, G., Frazer, A. & Aronson, C. Effect of Chronic Administration of Antidepressants on α2-Adrenoceptors in the Locus Coeruleus and Its Projection Fields in Rat Brain Determined by Quantitative Autoradiography. Neuropsychopharmacol 8, 57–65 (1993). https://doi.org/10.1038/npp.1993.7
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DOI: https://doi.org/10.1038/npp.1993.7
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