Abstract
We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.
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Acknowledgements
We appreciate the advice of A.S. Edge and F. Shi in developing the western blot analysis, that of B.P. Manning for the immunohistochemistry, that of C.E. Corrales in removing inner ears from mouse pups, and that of S. Heller for neuronal culture. We thank R.A. Eatock for critical comments on early versions of the manuscript. The work was supported by grants from the US National Institute on Deafness and Other Communication Disorders.
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Chen, Z., Kujawa, S. & Sewell, W. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci 10, 1238–1240 (2007). https://doi.org/10.1038/nn1974
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DOI: https://doi.org/10.1038/nn1974
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