Glial cells that express NG2 and platelet-derived growth factor receptor α are found throughout the mature CNS. These cells are mitotically active, but their functions remain enigmatic. A genetic fate-mapping study in this issue shows that these abundant glial cells can generate both oligodendrocytes and some cortical projection neurons in the adult brain.
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Change history
16 December 2008
In the version of this article initially published, in Figure 1c, mature oligodendrocytes are incorrectly labeled as ‘NeuN+’. This should be ‘NeuN–’. The error has been corrected in the HTML and PDF versions of the article.
References
Zhao, C., Deng, W. & Gage, F.H. Cell 132, 645–660 (2008).
Dawson, M.R., Polito, A., Levine, J.M. & Reynolds, R. Mol. Cell. Neurosci. 24, 476–488 (2003).
Rivers, L.E. et al. Nat Neurosci 11, 1392–1401 (2008).
Levine, J.M., Reynolds, R. & Fawcett, J.W. Trends Neurosci. 24, 39–47 (2001).
Bergles, D.E., Roberts, J.D., Somogyi, P. & Jahr, C.E. Nature 405, 187–191 (2000).
Lin, S.C. & Bergles, D.E. Nat. Neurosci. 7, 24–32 (2004).
Ziskin, J.L., Nishiyama, A., Rubio, M., Fukaya, M. & Bergles, D.E. Nat. Neurosci. 10, 321–330 (2007).
Kukley, M., Capetillo-Zarate, E. & Dietrich, D. Nat. Neurosci. 10, 311–320 (2007).
Chittajallu, R., Aguirre, A. & Gallo, V. J. Physiol. (Lond.) 561, 109–122 (2004).
Karadottir, R., Hamilton, N.B., Bakiri, Y. & Attwell, D. Nat. Neurosci. 11, 450–456 (2008).
Kondo, T. & Raff, M. Science 289, 1754–1757 (2000).
Menn, B. et al. J. Neurosci. 26, 7907–7918 (2006).
Zhu, X., Bergles, D.E. & Nishiyama, A. Development 135, 145–157 (2008).
Gould, E. Nat. Rev. Neurosci. 8, 481–488 (2007).
Dimou, L., Simon, C., Kirchhoff, F., Takebayashi, H. & Gotz, M. J. Neurosci. 28, 10434–10442 (2008).
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Kang, S., Bergles, D. Glial progenitor cells in the adult brain reveal their alternate fate. Nat Neurosci 11, 1365–1367 (2008). https://doi.org/10.1038/nn1208-1365
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DOI: https://doi.org/10.1038/nn1208-1365
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