Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Sensory-motor control: a long-awaited behavioral correlate of presynaptic inhibition

Presynaptic inhibition of cutaneous afferents influences sensory-motor responses in the spinal cord. In-vivo recordings in monkeys now show that this process suppresses the transmission of cutaneous signals generated during volitional movement.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Key neurons involved in the relay of cutaneous input, via first-order interneurons in the spinal cord, to segmental motor systems and higher sensory systems.

Erin Boyle

References

  1. Miller, R.J. Annu. Rev. Pharmacol. Toxicol. 38, 201–227 (1998).

    Article  CAS  Google Scholar 

  2. Rudomin, P. & Schmidt, R.F. Exp. Brain Res. 129, 1–37 (1999).

    Article  CAS  Google Scholar 

  3. Hultborn, H., Meunier, S., Pierrot-Deseilligny, E. & Shindo, M. J. Physiol. (Lond.) 389, 757–772 (1987).

    Article  CAS  Google Scholar 

  4. Capaday, C. & Stein, R.B. J. Neurosci. 6, 1308–1313 (1986).

    Article  CAS  Google Scholar 

  5. Seki, K., Perlmutter, S.I. & Fetz, E.E. Nat. Neurosci. 6, 1309–1316 (2003).

    Article  CAS  Google Scholar 

  6. Jankowska, E., Slawinska, U. & Hammar, I. J. Physiol. (Lond.) 542, 287–299 (2002).

    Article  CAS  Google Scholar 

  7. Rustioni, A. Science 196, 656–658 (1977).

    Article  CAS  Google Scholar 

  8. Shergill, S.S., Bays, P.M., Frith, C.D. & Wolpert, D.M. Science 301, 187 (2003).

    Article  CAS  Google Scholar 

  9. Williams, S.R., Shenasa, J. & Chapman, C.E. J. Neurophysiol. 79, 947–963 (1998).

    Article  CAS  Google Scholar 

  10. Andersen, P., Eccles, J.C., Schmidt, R.F. & Yokota, T. J. Neurophysiol. 27, 92–106 (1964).

    Article  CAS  Google Scholar 

  11. Scott, S.H. Curr. Opin. Neurobiol. (in press).

  12. Kalaska, J.F. & Crammond, D.J. Science 255, 1517–1523 (1992).

    Article  CAS  Google Scholar 

  13. Bortoff, G.A. & Strick, P.L. J. Neurosci. 13, 5105–5118 (1993).

    Article  CAS  Google Scholar 

  14. Robinson, D.A. in Basic Mechanisms of Ocular Motility and Their Clinical Implications (eds. Lennerstrand, G. & Bach-y-Rita, P.) 337–374 (Pergamon Press, Oxford, 1975).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rose, P., Scott, S. Sensory-motor control: a long-awaited behavioral correlate of presynaptic inhibition. Nat Neurosci 6, 1243–1245 (2003). https://doi.org/10.1038/nn1203-1243

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1203-1243

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing