Neural activity leads to the mobilization of energy from glycogen in astrocytes. A new paper reports that neurons have an ambivalent relationship with glycogen: they can synthesize it themselves, but that synthesis induces apoptosis. Presumably for this reason, neurons normally inhibit glycogen synthesis through two redundant pathways.
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Magistretti, P., Allaman, I. Glycogen: a Trojan horse for neurons. Nat Neurosci 10, 1341–1342 (2007). https://doi.org/10.1038/nn1107-1341
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DOI: https://doi.org/10.1038/nn1107-1341
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