Although many drug-induced neural changes are known, progress has been slow in identifying the ones that actually mediate addiction. Identifying changes that are specific to particular elements of the transition from initial to habitual to relapsing drug use may be a fruitful strategy for pinpointing which forms of drug-induced plasticity are critical for addiction.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen
Pharmacological Reports Open Access 31 December 2022
-
Cocaine Administration and Its Withdrawal Enhance the Expression of Genes Encoding Histone-Modifying Enzymes and Histone Acetylation in the Rat Prefrontal Cortex
Neurotoxicity Research Open Access 10 April 2017
-
Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine
Scientific Reports Open Access 05 November 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Keitz, M., Martin-Soelch, C. & Leenders, K.L. Neural Plast. 10, 121–128 (2003).
Wise, R.A. Nat Rev. Neurosci. 5, 483–494 (2004).
Robinson, T.E. & Berridge, K.C. Annu. Rev. Psychol. 54, 25–53 (2003).
Kauer, J.A. Annu. Rev. Physiol. 66, 447–475 (2004).
Kelley, A.E. Neuron 44, 161–179 (2004).
Jones, S. & Bonci, A. Curr. Opin. Pharmacol. 5, 20–25 (2005).
Koob, G.F. et al. Neurosci. Biobehav. Rev. 27, 739–749 (2004).
Nestler, E.J., Barrot, M. & Self, D.W. Proc. Natl. Acad. Sci. USA 98, 11042–11046 (2001).
Mackler, S.A. et al. J. Neurosci. 20, 6210–6217 (2000).
Szumlinski, K.K. et al. Neuropsychopharmacology published online 14 September 2005 (10.1038/sj.npp.1300890).
McClung, C.A. & Nestler, E.J. Nat. Neurosci. 6, 1208–1215 (2003).
Carlezon, W.A., Jr. & Nestler, E.J. Trends Neurosci. 25, 610–615 (2002).
Ahmed, S.H., Kenny, P.J., Koob, G.F. & Markou, A. Nat. Neurosci. 5, 625–626 (2002).
Vanderschuren, L.J. & Everitt, B.J. Science 305, 1017–1019 (2004).
Lu, L. et al. Nat. Neurosci. 8, 212–219 (2005).
Kalivas, P.W., Volkow, N. & Seamans, J. Neuron 45, 647–650 (2005).
Kalivas, P.W. & Volkow, N.D. Am. J. Psychiatry 162, 1403–1413 (2005).
Baker, D.A. et al. Nat. Neurosci. 6, 743–749 (2003).
Baptista, M.A., Martin-Fardon, R. & Weiss, F. J. Neurosci. 24, 4723–4727 (2004).
Canales, J.J. Neurobiol. Learn. Mem. 83, 93–103 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Kalivas, P. How do we determine which drug-induced neuroplastic changes are important?. Nat Neurosci 8, 1440–1441 (2005). https://doi.org/10.1038/nn1105-1440
Issue Date:
DOI: https://doi.org/10.1038/nn1105-1440
This article is cited by
-
Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen
Pharmacological Reports (2023)
-
Cocaine Administration and Its Withdrawal Enhance the Expression of Genes Encoding Histone-Modifying Enzymes and Histone Acetylation in the Rat Prefrontal Cortex
Neurotoxicity Research (2017)
-
Metabolic characterization in urine and hair from a rat model of methamphetamine self-administration using LC-QTOF-MS-based metabolomics
Metabolomics (2017)
-
Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine
Scientific Reports (2015)
-
Reducing substance use during adolescence: a translational framework for prevention
Psychopharmacology (2014)