Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fast adaptation in the mammalian cochlea: a conserved mechanism for cochlear amplification

In fish and amphibians, auditory cells use a rapid channel reclosure mechanism to amplify and discriminate sound stimuli. New evidence from Kennedy et. al. suggests that mammalian outer hair cells also use a similar form of fast adaptation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fast adaptation in hair cells.

References

  1. Robles, L. & Ruggero, M.A. Physiol. Rev. 81, 1305–1352 (2001).

    Article  CAS  Google Scholar 

  2. Fettiplace, R., Ricci, A.J. & Hackney, C.M. Trends Neurosci. 24, 169–175 (2001).

    Article  CAS  Google Scholar 

  3. Kennedy, H.J., Evans, M.G., Crawford, M.C. & Fettiplace, R. Nat. Neurosci. 6, 832–836 (2003).

    Article  CAS  Google Scholar 

  4. Gillespie, P.G. & Walker, R.G. Nature 413, 194–202 (2001).

    Article  CAS  Google Scholar 

  5. Dallos, P. & Fakler, B. Nat. Rev. Mol. Cell. Biol. 3, 104–111 (2002).

    Article  CAS  Google Scholar 

  6. Liberman, M.C. et al. Nature 419, 300–304 (2002).

    Article  CAS  Google Scholar 

  7. Liu, X.Z. et al. Hum. Mol. Genet. 12, 1155–1162 (2003).

    Article  CAS  Google Scholar 

  8. Ricci, A.J., Crawford, A.C. & Fettiplace, R. J. Neurosci. 20, 7131–7142 (2000).

    Article  CAS  Google Scholar 

  9. Ricci, A.J. & Fettiplace, R. J. Physiol. (Lond.) 501, 111–124 (1997).

    Article  CAS  Google Scholar 

  10. Kros, C.J., Rüsch, A. & Richardson, G.P. Proc. R. Soc. Lond. B. Biol. Sci. 249, 185–193 (1992).

    Article  CAS  Google Scholar 

  11. Ricci, A.J. & Fettiplace, R. J. Physiol. (Lond.) 506, 159–173 (1998).

    Article  CAS  Google Scholar 

  12. Weber, T. et al. Proc. Natl. Acad. Sci. USA 100, 7690–7695 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strassmaier, M., Gillespie, P. Fast adaptation in the mammalian cochlea: a conserved mechanism for cochlear amplification. Nat Neurosci 6, 790–791 (2003). https://doi.org/10.1038/nn0803-790

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0803-790

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing