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Mutant huntingtin goes straight to the heart

New findings suggest that the mutant form of the huntingtin protein, which causes Huntington's disease, may damage neurons by directly interfering with mitochondrial function.

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Figure 1: A possible chain of events leading to neuronal death in Huntington's disease.

References

  1. The Huntington's Disease Collaborative Research Group. Cell 72, 971–983 (1993).

  2. Sipione, S. & Cattaneo, E. Mol. Neurobiol. 23, 21–51 (2001).

    Article  CAS  Google Scholar 

  3. Rubinsztein, D.C. Trends Genet. 18, 202–209 (2002).

    Article  CAS  Google Scholar 

  4. Cattaneo, E. et al. Trends Neurosci. 24, 182–188 (2001).

    Article  CAS  Google Scholar 

  5. Panov, A.V. et al. Nat. Neurosci. 5, 731–736 (2002).

    Article  CAS  Google Scholar 

  6. Crompton, M. Biochem. J. 341, 233–249 (1999).

    Article  CAS  Google Scholar 

  7. Hodgson, J.G. et al. Neuron 23, 181–192 (1999).

    Article  CAS  Google Scholar 

  8. Beal, M.F. Trends Neurosci. 23, 298–304 (2000).

    Article  CAS  Google Scholar 

  9. Sawa, A. et al. Nat. Med. 5, 1194–1198 (1999).

    Article  CAS  Google Scholar 

  10. Zeron, M.M. et al. Neuron 33, 849–860 (2002).

    Article  CAS  Google Scholar 

  11. Kim, Y.J. et al. Proc. Natl. Acad. Sci. USA 98, 12784–12789 (2001).

    Article  CAS  Google Scholar 

  12. Rigamonti, D. et al. J. Neurosci. 20, 3705–3713 (2000).

    Article  CAS  Google Scholar 

  13. Dragatsis, I., Levine, M.S. & Zeitlin, S. Nat. Genet. 26, 300–306 (2000).

    Article  CAS  Google Scholar 

  14. Calabresi, P. et al. J. Neurosci. 21, 5110–5120 (2001).

    Article  CAS  Google Scholar 

  15. Zuccato, C. et al. Science 293, 493–498 (2001).

    Article  CAS  Google Scholar 

Download references

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Cattaneo, E., Calabresi, P. Mutant huntingtin goes straight to the heart. Nat Neurosci 5, 711–712 (2002). https://doi.org/10.1038/nn0802-711

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