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A chemokine–glutamate connection

Chemokine signaling releases glutamate from astrocytes. This process can be amplified by microglia, inducing neurotoxicity, and activated by the HIV coat protein gp120.

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Figure 1: Chemokine (SDF-1) signaling leading to glutamate release from astrocytes.

Bob Crimi

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Allen, N., Attwell, D. A chemokine–glutamate connection. Nat Neurosci 4, 676–678 (2001). https://doi.org/10.1038/89443

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