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Inhibition by an excitatory conductance: a paradox explained

Nature Neuroscience volume 12, pages 530–532 (2009)Cite this article

Ih is an excitatory inward current at subthreshold voltages, but enhancing Ih in CA1 pyramidal neurons leads to inhibition of action potential firing. A report in this issue suggests activation of the potassium current IM underlies this paradox.

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Figure 1: The anticonvulsant drug lamotrigine enhances Ih and depresses excitability in CA1 pyramidal neurons.

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  1. The author is in the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. bruce_bean@hms.harvard.edu,

    Bruce P Bean

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  1. Bruce P Bean
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Bean, B. Inhibition by an excitatory conductance: a paradox explained. Nat Neurosci 12, 530–532 (2009). https://doi.org/10.1038/nn0509-530

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