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What a privilege to reside at the synapse: NMDA receptor signaling to CREB

Nature Neuroscience volume 5, pages 389–390 (2002)Cite this article

NMDA receptors are important for both normal transmission and pathological damage. New results indicate that receptor location makes the key difference: survival-promoting signals derive from synaptic receptors, whereas a cell-death signal comes from extrasynaptic receptors.

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Figure 1: Activation of extrasynaptic NMDA receptor signaling triggers a CREB 'shut-off' pathway.

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Authors and Affiliations

  1. The authors are in the Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, 21205-2185, Maryland, USA

    Antonella Riccio & David D. Ginty

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  1. Antonella Riccio
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  2. David D. Ginty
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Riccio, A., Ginty, D. What a privilege to reside at the synapse: NMDA receptor signaling to CREB. Nat Neurosci 5, 389–390 (2002). https://doi.org/10.1038/nn0502-389

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