How neurons might protect themselves from free radical damage has been a mystery. A new study suggests that synaptic NMDA receptor activity affords neuroprotection by regulating oxidation-reduction (redox) pathways via transcription.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation
Scientific Reports Open Access 11 April 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Papadia, S. et al. Nat. Neurosci. 11, 476–487 (2008).
Fang, J., Nakamura, T., Cho, D.H., Gu, Z. & Lipton, S.A. Proc. Natl. Acad. Sci. USA 104, 18742–18747 (2007).
Gu, Z. et al. Science 297, 1186–1190 (2002).
Rhee, S.G., Jeong, W., Chang, T.S. & Woo, H.A. Kidney Int. Suppl. 106, S3–S8 (2007).
Hardingham, G.E. & Bading, H. Trends Neurosci. 26, 81–89 (2003).
Lipton, S.A. Nat. Rev. Neurosci. 8, 803–808 (2007).
Lipton, S.A. Nat. Rev. Drug Discov. 5, 160–170 (2006).
Liu, Y. et al. J. Neurosci. 27, 2846–2857 (2007).
Chung, K.K. et al. Science 304, 1328–1331 (2004).
Yao, D. et al. Proc. Natl. Acad. Sci. USA 101, 10810–10814 (2004).
Lipton, S.A. et al. Science 308, 1870 (2005).
Uehara, T. et al. Nature 441, 513–517 (2006).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
Dr. Lipton is the named inventor on patents for the use of the clinically-approved and marketed drug, memantine (Namenda®), in the treatment of neurodegenerative diseases. He has no direct ownership in memantine, but under the rules of the institution where this work was performed, Harvard University, he participates in a royalty-sharing plan administered by Harvard Medical School and Children's Hospital, Bostan.
Rights and permissions
About this article
Cite this article
Lipton, S. NMDA receptor activity regulates transcription of antioxidant pathways. Nat Neurosci 11, 381–382 (2008). https://doi.org/10.1038/nn0408-381
Issue Date:
DOI: https://doi.org/10.1038/nn0408-381
This article is cited by
-
Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation
Scientific Reports (2017)
-
The role of glutamate and its receptors in multiple sclerosis
Journal of Neural Transmission (2014)
