The neurodevelopmental disorder Rett syndrome involves mutations in the transcriptional repressor MECP2. Two groups now show a role for MECP2 in postmitotic mouse neurons.
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The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome
BMC Neuroscience Open Access 08 August 2011
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Carter, A., Segal, R. Rett syndrome model suggests MECP2 gives neurons the quiet they need to think. Nat Neurosci 4, 342–343 (2001). https://doi.org/10.1038/85970
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DOI: https://doi.org/10.1038/85970
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