The floor plate can generate neurons, but does so only in the midbrain. New work shows that Shh suppresses floor plate neurogenesis, and that in the midbrain, Wnt downregulates Shh expression via canonical signaling through β-catenin.
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Fasano, C., Studer, L. Too much Sonic, too few neurons. Nat Neurosci 12, 107–108 (2009). https://doi.org/10.1038/nn0209-107
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DOI: https://doi.org/10.1038/nn0209-107
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Embryonic development of selectively vulnerable neurons in Parkinson’s disease
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