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A new form of long-term depression in the perirhinal cortex

Nature Neuroscience volume 3, pages 150–156 (2000)Cite this article

Abstract

We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation may be necessary for induction of LTD at resting membrane potentials. However, depolarization enhanced NMDA receptor function and removed the requirement of synergy between group I and group II mGlu receptors: under these conditions, activation of only NMDA and group I mGlu receptors was required for LTD. Such glutamate receptor interactions potentially provide new rules for synaptic plasticity. These forms of LTD occur in the perirhinal cortex, where long-term decreases in neuronal responsiveness may mediate recognition memory.

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Figure 1: The perirhinal cortex.
Figure 2: LTD relies on activation of NMDA receptors and a postsynaptic increase in calcium.
Figure 3: LTD depends on group I but not group III mGlu receptor activation.
Figure 4: The role of group II mGlu receptors in LTD is voltage dependent.
Figure 5: The role of group II mGlu receptors in LTD is influenced by the level of NMDA receptor activation.
Figure 6: Group II mGlu receptor activation by DCG-IV enhances group I mGlu receptor (DHPG)-induced inward current and calcium mobilization.

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Acknowledgements

We thank A. Doherty, L. Pickard and V. Collett for help with cell culture and calcium imaging and G.L. Collingridge for discussions. This work was supported by the BBSRC, MRC and Wellcome Trust.

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Author notes

  1. J. Noel

    Present address: Biologie cellulaire des compartiments calciques, Universite de Nice-Sophia Antipolis, Faculte des sciences, 06108, Nice, France

Authors and Affiliations

  1. MRC Centre for Synaptic Plasticity, Dept. of Anatomy, University of Bristol, Bristol, BS8 1TD, UK

    K. Cho, N. Kemp, J. Noel, M. W. Brown & Z. I. Bashir

  2. School of Psychology, Cardiff University, Cardiff, CF10 3YJZ, UK

    J. P. Aggleton

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Correspondence to Z. I. Bashir.

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Cho, K., Kemp, N., Noel, J. et al. A new form of long-term depression in the perirhinal cortex. Nat Neurosci 3, 150–156 (2000). https://doi.org/10.1038/72093

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