Abstract
Retinal amacrine cells are thought to lack chromatic or color-selective light responses and have only a minor role in color processing. We found that a type of mammalian (Ictidomys tridecemlineatus) amacrine cell selectively carries a blue-On signal, which is received from a blue or short wavelength–sensitive (S) cone On bipolar cell. This glycinergic inhibitory S-cone amacrine cell is ideally placed for driving blue-Off responses in downstream ganglion cells.
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Acknowledgements
We thank D. Merriman and T. Rosenberg for editing and S. DeVries and B. Szmajda for critically reading the manuscript. This work was supported by the Intramural Research Program of the National Eye Institute (ZIA EY000508-01).
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S.C. and W.L. conceived the project and designed the experiments. S.C. performed the experiments. S.C. and W.L. analyzed the data. W.L. wrote the manuscript.
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Chen, S., Li, W. A color-coding amacrine cell may provide a blue-Off signal in a mammalian retina. Nat Neurosci 15, 954–956 (2012). https://doi.org/10.1038/nn.3128
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DOI: https://doi.org/10.1038/nn.3128
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